Journal article
Benjamin L. Rice, J. Lessler, Clifton D. McKee, C. Metcalf
PLoS Biology, 2022
PLoS Biology, 2022
Semantic Scholar
DOI
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APA
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Rice, B. L., Lessler, J., McKee, C. D., & Metcalf, C. (2022). Why do some coronaviruses become pandemic threats when others do not? PLoS Biology.
Chicago/Turabian
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Rice, Benjamin L., J. Lessler, Clifton D. McKee, and C. Metcalf. “Why Do Some Coronaviruses Become Pandemic Threats When Others Do Not?” PLoS Biology (2022).
MLA
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Rice, Benjamin L., et al. “Why Do Some Coronaviruses Become Pandemic Threats When Others Do Not?” PLoS Biology, 2022.
BibTeX Click to copy
@article{benjamin2022a,
title = {Why do some coronaviruses become pandemic threats when others do not?},
year = {2022},
journal = {PLoS Biology},
author = {Rice, Benjamin L. and Lessler, J. and McKee, Clifton D. and Metcalf, C.}
}
Abstract
Despite multiple spillover events and short chains of transmission on at least 4 continents, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has never triggered a pandemic. By contrast, its relative, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has, despite apparently little, if any, previous circulation in humans. Resolving the unsolved mystery of the failure of MERS-CoV to trigger a pandemic could help inform how we understand the pandemic potential of pathogens, and probing it underscores a need for a more holistic understanding of the ways in which viral genetic changes scale up to population-level transmission.
